Exploring Solutions

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Driving Innovation Through Research

At Pet Longevity, we don’t just explore the challenges pets face after neutering and spaying — we work to solve them. Through the Million Pet Study, we’re breaking new ground in veterinary research to uncover the solutions pets need to live longer, healthier, and happier lives.

The hormonal changes that occur after neutering and spaying—what we call “menopaws”—can lead to long-term health challenges, from metabolic disorders and joint issues to cognitive decline and behavioral changes. Despite the parallels with human conditions like menopause and andropause, veterinary science has lagged behind in addressing these critical issues. That’s where our work comes in.

Our research focuses on the transformative potential of hormone replacement therapy (HRT) to restore balance, prevent disease, and enhance quality of life. By gathering robust data, testing innovative protocols, and collaborating with veterinarians worldwide, we’re developing practical, evidence-based tools that redefine what’s possible in pet care.

What Sets Us Apart:

  • A mission to bridge the gap between human medical advancements and veterinary science.
  • Ongoing studies that focus on safe, effective dosing and implementation of HRT for pets.
  • Collaboration with leading veterinarians to bring cutting-edge solutions to clinics everywhere.

How You Can Be Part of the Solution:

  • Interested in starting your pets on hormone replacement therapy? Inquire here
  • Help your pet’s veterinarian stay informed—connect us with their practice to share our latest findings.
  • Join the movement for better pet health—sign up for updates and support our mission.

Replacing hormones that were removed by a spay or neuter not only reduces the risk of orthopedic issues but can also potentially increase your dog's lifespan.

- Dr. Karen Becker

Health Challenges Driving the Study

“They need to take a serious look at this,” said Hart. “Joint disorders can shorten a dog’s useful working life and impact its role as a family member.”
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Compared to intact dogs, all gonadectomy age categories showed increased risk for the development of overweight/obesity.

-Simpson M, Albright S, Wolfe B, Searfoss E, Street K, Diehl K, Page R. Age at gonadectomy and risk of overweight/obesity and orthopedic injury in a cohort of Golden Retrievers. PLoS One. 2019 Jul 17;14(7):e0209131. doi: 10.1371/journal.pone.0209131. PMID: 31314808;
PMCID: PMC6636707.

Negative associations between neuter status, and health conditions have been reported in recent years
-Oberbauer AM, Belanger JM, Famula TR. A Review of the Impact of Neuter Status on Expression of Inherited Conditions in Dogs. Front Vet Sci. 2019 Nov 13;6:397. doi: 10.3389/fvets.2019.00397. PMID: 31799281; PMCID: PMC6863800.

Weekly subcutaneous administration of testosterone cypionate (0.5 mg/kg) significantly
reduced pain and increased muscle mass, thereby improving mobility

-Brent L, Lissner EA, Kutzler MA. Restoration of Reproductive Hormone Concentrations in a Male Neutered Dog Improves Health: A Case Study. Top Companion Anim Med. 2021 Nov;45:100565. doi: 10.1016/j.tcam.2021.100565. Epub 2021 Jul 28. PMID: 34332118.

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